Methamphetamine and MDMA (Ecstasy) Neurotoxicity: 'of Mice and Men'
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چکیده
منابع مشابه
Recreational Ecstasy/MDMA, the serotonin syndrome, and serotonergic neurotoxicity.
The ring-substituted amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) or "Ecstasy" is widely used a recreational drug. It stimulates the release and inhibits the reuptake of serotonin (5-HT) and other neurotransmitters such as dopamine to a lesser extent. The acute boost in monoamine activity can generate feelings of elation, emotional closeness, and sensory pleasure. In the hot ...
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The majority of MDMA (ecstasy) recreational users also consume cannabis. Despite the rewarding effects that both drugs have, they induce several opposite pharmacological responses. MDMA causes hyperthermia, oxidative stress and neuronal damage, especially at warm ambient temperature. However, THC, the main psychoactive compound of cannabis, produces hypothermic, anti-inflammatory and antioxidan...
متن کاملNeurotoxicity of drugs of abuse - the case of methylenedioxy amphetamines (MDMA, ecstasy ), and amphetamines
Ecstasy (MDMA, 3,4-methylendioxymethamphetamine) and the stimulants methamphetamine (METH, speed) and amphetamine are popular drugs among young people, particularly in the dance scene. When given in high doses both MDMA and the stimulant amphetamines are clearly neurotoxic in laboratory animals. MDMA causes selective and persistent lesions of central serotonergic nerve terminals, whereas amphet...
متن کاملEcstasy: pharmacology and neurotoxicity.
In part because it is amphetamine derived, ecstasy has inherited some of its parent compound's reputation for being neurotoxic. However, whereas amphetamine and methamphetamine undoubtedly cause irreversible brain damage with long-term use, the jury is still out on the party drug ecstasy. The deadly reputation of ecstasy has been fuelled by the tragic fates of healthy young clubbers who have di...
متن کاملThe Role of Agonist of A2a Adenosine Receptors on Neurotoxicity of Mdma (Ecstasy Pill) on Rat’S Hippocampus
Purpose: MDMA is a synthetic drug that is originated from Amphetamine. It is used by some people. This material induces some chemical changes in serotonergic and dopaminergic neurons in middle brain. Materials and Methods: In this study, we used 49 Rats Sprague-Dawley, 200-250 gr. There were 7 groups and 7 Rats in each group. Rats received MDMA in the first group, in the second group CGS (A2A r...
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ژورنال
عنوان ژورنال: IUBMB Life (International Union of Biochemistry and Molecular Biology: Life)
سال: 2004
ISSN: 1521-6543,1521-6551
DOI: 10.1080/15216540410001727699